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It is interesting to know that, despite the whole face sun exposure, only some areas, specifically those with concentrated sebaceous glands including the forehead, cheeks, and upper lips are more commonly affected by melasma

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Studies suggest that C-peptide and insulin together provide greater renal protection than insulin alone, highlighting the idea of complete replacement therapy. 5

Conventional treatments for Graves disease, including antithyroid medications, radioactive iodine therapy, and thyroidectomy, often present significant challenges for patients

Alcohol consumption can also play a role

The mechanism explaining this selectivity is straightforward