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[PUBMED Abstract] Hancock BW, Wheatley K, Harris S, et al.: Adjuvant interferon in high-risk melanoma: the AIM HIGH Study--United Kingdom Coordinating Committee on Cancer Research randomized study of adjuvant low-dose extended-duration interferon Alfa-2a in high-risk resected malignant melanoma

Previous studies in mouse models demonstrated that CCL6 promotes innate immunity via immune cell activation, and serves as a chemoattractant for CD11b+ effector immune cells with the enhanced ability to generate IFN-, such as NK cells [51, 52]

4 shows an example of age-related increase in MRI-visible PVS