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The significance of this weak binding to IGFBPs is that the compound can exert more pharmacological action in animal subjects since IGFBPs decrease the pharmacological activity of hormones that are strongly bound to it

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As a result, Saxenda carries a black box warning an FDA-mandated safety alert based on potential risks rather than a confirmed link

Severe adverse events such as anaphylaxis are exceedingly rare fewer than 1 in 10,000 injections based on pharmacovigilance data from compounding pharmacy networks

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