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Effects of disease states on intra-portal insulin levels and changes in the GH/IGF-I axis High GH and low IGF-I Type 1 diabetes is an autoimmune disease characterized by pancreatic -cell destruction leading to intra-portal hypoinsulinemia

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Proc Am Assoc Cancer Res 44:23, 2003

The dose titration was performed to minimize GLP-1A-associated side effects

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Because GH pulses most strongly during sleep, timing is part of the design rather than an afterthought