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More recent DSIP and DSIP-analogue research, involving modified compounds designed to behave similarly to DSIP, has explored possible neuroprotective and stroke-recovery roles in animal models, but this work remains preclinical rather than validated through large human therapeutic trials [1112][1819]

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It has been reported that patients with UC show increased levels of DNA oxide, enhanced ROS production in neutrophils, and decreased antioxidant mechanisms 14

Acknowledgments The authors thank the staff of the SQU Small Animal House for looking after the animals

Melatonin from Cerebrospinal Fluid but Not from Blood Reaches Sheep Cerebral Tissues under Physiological Conditions

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