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Influences HPA axis regulation and cortisol dynamics: The hypothalamic-pituitary-adrenal (HPA) axis governs physiological stress responses through sequential CRH, ACTH, and cortisol release

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The mechanism: KPV translocates into the cell nucleus and blocks the interaction between importin-alpha3 and the p65/RelA subunit of NF-kB, preventing p65 from reaching its transcriptional targets

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