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Namely, proteinprotein and protein-DNA interactions are disrupted by GST tag crosslinking, which results in functional inactivation of the fused protein
They resist degradation due to factors like heat, ultraviolet light, and air
These genetic associations may be drug-specific
This review synthesizes evidence from peer-reviewed studies published between 2020 and 2026, prioritizing systematic reviews, meta-analyses, and large-scale clinical trials from PubMed-indexed journals
Similarly, targeting other metabolic complexes or enzymes is restricted by their toxicity to normal tissues
[DOI] [PubMed] [Google Scholar] 55.Olsen R.K.J., Koakov E., Giancaspero T.A., Mosegaard S., Boczonadi V., Matakovi L., Veauville-Merlli A., Terrile C., Schwarzmayr T., Haack T.B., et al
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