Trigonelline can decrease the expression of Nrf2 in cancer cells and enhance the effects of chemotherapy, according to an investigation employed on H6c7 pancreatic duct cells and pancreatic carcinoma cell lines as models (Arlt et al., 2013)
High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors
A recent study has shown that people who take such drugs often regain all the weight they have lost within a year of halting the medication
both remain in clinical development, and their specific combination does not exist as a registered investigational product
Egerod KL, Petersen N, Timshel PN, Rekling JC, Wang Y, Liu Q, et al
Oral GLP-1 receptor agonists also present advantages: The small-molecule candidate orforglipron will complete its Phase III trial in 2025 and, if successful, may offer a lower-cost oral alternative to injectable therapies