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Expert Opinion on Investigational Drugs

Despite substantial advances in genetic and molecular research, effective treatments for BBS remain elusive, largely due to the limited understanding of the underlying pathophysiology

doi: 10.1016/j.jada.2007.07.017

There are reports on PKA-independent activation of GLP-1 via PLC/PKC pathway 1

Administered as a once-weekly subcutaneous injection, tirzepatide works by enhancing insulin secretion, suppressing glucagon release, and slowing gastric emptying, thereby improving glycaemic control

After the first four weeks at 2 mg, most protocols move to 4 mg for another four weeks, then 8 mg, and finally 12 mg