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PROMOTES DETOXIFICATION: Glutathione conjugation (facilitated by glutathione transferase enzymes) helps contribute to detoxification by binding electrophiles that would otherwise bind to proteins or nucleic acids, resulting in cellular damage

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Further investigation in this area could provide the basis for chronotherapeutic approaches in stroke and identify novel strategies to protect the BBB through circadian regulation

Gap closure can be affected by both cell movement and cell division, so the two effects should be separated when possible

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Relative contraindications (metformin use, PPIs, H2-blockers) warrant monitoring but do not always prevent treatment