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The drug significantly reduced the chronic inflammatory response and oxidative stress ( Novel dual- Glucagon-like peptide 1/glucose-dependent insulinotropic peptide receptor agonists are protective in animal models of Alzheimers disease The dual-receptor agonist DA3-CH that does not have any modifications, such as acylation to increase the survival time in the blood, enters the brain easier and shows good neuroprotective effects in the APP/PS1 mouse model

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In Figure 6B, immunofluorescence staining of 3D skin showed that RGD-GHK induced 2-fold upregulation of FLG and LOR proteins compared to the control and GHK