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Dose-response data shows a logarithmic curve: increasing dose from 20 mcg to 30 mcg produces meaningful improvement in recovery velocity, but increasing from 40 mcg to 60 mcg produces no additional benefit while doubling side effect incidence

5b, Supplementary Table 3)

trials used a stepwise dose-escalation approach at Q4W In TRIUMPH-3, 12mg reduced TGs, non-HDL cholesterol, systolic BP, waist circumference, & hsCRP by 37%, 16.5%, 9.3mmHg, 19cm, & 51.2%, respectively

The Centers for Disease Control and Prevention (CDC) has also issued guidelines on how and when to use opioids for chronic pain