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For enrichment analysis, isotopically labeled glucose ( 13 C 6 glucose), acetate ( 13 C 2 acetate), or palmitate ( 13 C 16 palmitate) was added to culture media and the enrichment into acyl-CoAs was determined using FluxFix based on samples treated with no isotope tracer 48

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573 Hence, a better understanding of the interplay between key cellular compartments, cellular niche and the transcriptional co-activators will help identify alternative therapeutic targets