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10.1371/journal.pone.0137837 25 FengW

Myocardial infarction Myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow to a part of the heart muscle is blocked, leading to ischemia and tissue damage

Catechol docked on TNF- (pdb id- 2AZ5) and VEGFA (pdb id- 1CZ8) showed the highest binding affinity ( 4.3 Kcal/Mol and 4.159 Kcal/Mol respectively) and formed H-bond and several hydrophobic interactions

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Practices such as inadequate dosing, inappropriate treatment regimens, the free availability of drugs, management of patients by unqualified persons, and incomplete treatment courses have led to the development of subtherapeutic levels of antimony in the blood, promoting parasite tolerance and resistance to the drug (Kazemi-Rad et al., 2013)