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1 2 DellaValle B, Brix GS, Brock B, Gejl M, Landau AM, Mller A, Rungby J, Larsen A (2016)

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Aggressive home remedies (lemon juice, baking soda, undiluted vitamin C, harsh exfoliants) typically worsen lip pigmentation by triggering post-inflammatory hyperpigmentation around the macule itself

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While mTORC2 primarily promotes cell proliferation and survival through the phosphorylation of AKT, many tumors need mTORC1 to maintain their ability to control protein synthesis and cell growth, as well as to coordinate nutrient and energy supply to ensure that they undergo unrestricted cell division (103)