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3 GLP-1 signaling reaches the brain through both direct hormone signaling and broader gut-brain communication pathways involved in appetite regulation

This anabolic effect contributes to muscle hypertrophy, allowing for the development of larger and stronger muscle fibres over time (2)

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It also reduces the amount of sugar the liver produces, slows down the emptying of the stomach, and makes you feel full sooner, which can help with weight loss

Tirzepatide, which produces some of the largest weight reductions seen in clinical trials, sits at the center of this research