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Evidence of secondary coenzyme Q 10 deficiency has been reported in several mitochondrial disorders, such as mitochondrial DNA depletion syndrome, Kearns-Sayre syndrome, or multiple acyl-CoA dehydrogenase deficiency (MADD) (10)

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The long term effects include heightened risk of respiratory depression , CNS suppression , and potentially fatal overdose complications

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Patients received standard therapy with a GH dose identical to each subject's prestudy therapy, with median 33 (range 1346) mcg/kg/d