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2 Although the pancreatic effects of GLP-1 (glucose-dependent insulin secretion and glucagon suppression) are well-established, its extrapancreatic actions are increasingly being recognised as critical to the therapeutic effects of GLP-1RAs

Answer: Retatrutide is not FDA approved as of April 2026 and not EMA approved either

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"Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults." Annals of Internal Medicine 149.9 (2008): 601-611

Multifaceted mechanisms of vascular calcification in aging