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Sickle cell anaemia

T., Lin, S

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Second, safety and ethical concerns persist, particularly for injectable systems such as PEGylated uricase, where immunogenicity and long-term tissue accumulation necessitate rigorous riskbenefit analyses

Importantly, despite the enhanced formation of hydrogen peroxide in the dismutation reaction, LPO is very limited

In rare cases, more serious side effects such as pancreatitis, kidney problems, bowel obstruction, or allergic reactions can occur