We were surprised by our findings given many case reports of patients who had recently taken GLP-1 receptor agonists and had a large volume of gastric contents found under anesthesia, even if they had appropriately withheld these medications and fasted for the recommended times before surgery, said Anjali Dixit, MD, MPH, a pediatric anesthesiologist and clinical and postdoctoral scholar in anesthesiology, perioperative and pain medicine at Stanford Medicine
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doi: 10.1038/npp.2016.143 60 FletcherJ
Starting with a low semaglutide dose of 0.25 mg allows the body to adjust gradually, minimizing the risk of adverse effects, particularly gastrointestinal symptoms common at the beginning of treatment
They are often broken down by stomach acid before they can reach the small intestine
