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The arbutin-tyrosinase complexes demonstrated remarkable conformational consistency throughout MD simulations, with RMSD analysis and binding free energy (Fig

Further investigations indicated that the age of patients with type 2 diabetes does not affect the glycemic efficacy of oral semaglutide and the presence of upper gastrointestinal disease, or that hepatic impairment did not affect the pharmacokinetics of semaglutide [61]

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In particular, APX has a higher affinity for H 2 O 2 and reduces it to H 2 O in chloroplasts, cytosol, mitochondria and peroxisomes, as well as in the apoplastic space, utilizing ascorbate as specific electron donor