It mimics the actions of two natural hormones: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which regulate appetite and blood sugar levels
9 In addition, secretion is regulated by thyroid hormones, leptin, androgens, and estrogen
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Risk ratios (RR) for the renal outcome estimates according to direct (DPP-4 inhibitors, GLP-1RA and SGLT-2 inhibitors against placebo) and indirect (DPP-4 inhibitors vs GLP-1RA or SGLT-2 inhibitors, and GLP-1RA vs SGLT-2 inhibitors) comparisons
The injectable GLP-1 semaglutide (Ozempic) can now be dosed up to 2.0mg a week