In fact, the Institute of Medicine recommends that adults aged 51 and over take vitamin B12 shots because they are more bioavailable than vitamin B12 found in oral supplements and foods
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However, two cases of transient and mild adverse effects, including nausea and headache, were reported during the initial phase of treatment [145]
Neil Johnson highlighted that the gastrointestinal issues associated with metformin can sometimes lead to patients discontinuing the treatment altogether
The absolute risk for these complications however is extremely uncommon, less than 1 per cent per year of use (Eckert)
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