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The FDA approval is currently for adults with: A body mass index (BMI) of 30 or greater (obesity), or A BMI of 27 or greater (overweight) with at least one weight-related condition such as type 2 diabetes, high blood pressure, or high cholesterol The pill is not currently approved for type 1 diabetes (T1D) management, and the OASIS 4 trial excluded people with type 2 diabetes though that research is ongoing

PMID 8780094

Individual variation in GLP-1 receptor expression and gastrointestinal motility explains why one person tolerates a dose easily while another experiences significant symptoms at the same level

Adjustment Criteria: Decisions on treatment changes depend on the initial deficiency level, neurological symptoms, and how well the patient responds

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The continuation of compounding will likely continue the debate around the safety of compounded products