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however, sitagliptin was chosen as an active comparator because it is widely available in Japan,8 and has a wellknown efficacy and safety profile

However, delayed gastric emptying may intensify nausea, bloating, or fullness sensations, particularly during dose escalation phases

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Since semaglutide does not produce these metabolites, it remains undetected

The SUSTAIN-6 CV outcomes trial in particular drove the FDA approval for cardiovascular risk reduction in adults with diabetes and established CVD