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Briefly, cartilage slices were digested with 0.25% trypsin (Lonza, Belgium) for 30 minutes and then incubated for 46 h in Dulbeccos modified Eagles medium/F-12 (DMEM/F-12

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Dungan reports research support from Abbott, Dexcom, Sanofi and ViaCyte

Oxidative stress is caused by excess free radicals and has been linked to conditions including diabetes, cancer, heart disease, and stroke