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Unfortunately, a phase II clinical trial of UBX0101 (NCT03513016) was completed in patients with osteoarthritis and the promising results observed (Table 1), in vitro and in vivo, have not been up to the expectations in treated patients, leading only to a decrease of pain, without a significant improvement of the disease 30

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Chu Y, Dodiya H, Aebischer P et al (2009) Alterations in lysosomal and proteasomal markers in Parkinsons disease: relationship to alpha-synuclein inclusions

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88 Notably, antagonism of GH signaling has the added benefit of suppressing the IGF1-mediated effects, which contribute to the etiology of several disease indications in a manner similar to that described above

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