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The final covariate models for subject ( i ) and dosing occasion ( j ) were parameterised as follows: where In the above equations, is the estimated (or fixed) value for each covariate, ka.long.fast is the absorption rate constant for fasting times of 120 min or longer, i is the subject-level random effects, j is the occasion-level random effects

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On day 6, probe trials were conducted 1 and 24h post-training