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[3] Gout is a disease caused by elevated circulating levels of uric acid and is characterized by recurrent attacks of tender, hot, and painful joints

MMs with KIT mutations presumably affect the function of juxta-membrane autoinhibitory domain (JMD) (W557R, N566D, V559A, V559D, V560D, V569G, P573L, L576P, K642E) and tyrosine kinase domains (D816H, D820Y, A829P, N822K), causing constitutive activation of C-KIT-regulated pathways (8184)

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Semaglutide's ability to induce this physical response led to its emergence as a diabetes-treating medication almost 20 years ago

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