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In the STEP 1 trial, about 10% of participants achieved less than 5% weight loss, roughly the same as placebo response

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They started tirzepatide six months ago and only now notice increased shedding, so they blame stress, seasonal changes, or aging instead of recognizing the medication-triggered pattern

The Phase 2 NEJM trial mapped this relationship across four dose tiers, and the Phase 3 TRIUMPH-4 data confirmed it at scale (Jastreboff et al., NEJM, 2023)

Ginger Vieira Author Ginger Vieira has lived with type 1 diabetes and celiac disease since 1999, and fibromyalgia since 2014