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Sordi Pax6 haploinsufficiency causes abnormal metabolic homeostasis by down-regulating GLP-1 in mice

doi: 10.1038/nature08894

These side effects may require significant attention if setmelanotide were to be administered at doses efficacious for general obesity

It impacts how fat is made (lipogenesis) and how fat is broken down (lipolysis)

These findings confirm the fundamental role played by GLP-1 in the treatment of obesity and T2D, but suggest the need for further investigation of its exact mechanisms of action, as well as of possible differential effects of circulating levels of GLP-1 and administration of GLP-1R agonists

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