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doi:10.1016/j.amjmed.2020.08.010 7

in the absence of validated data, a conservative approach is appropriate discard sooner rather than later if there is any doubt Lyophilised (unreconstituted) vials should be stored according to the supplier's or trial protocol's instructions

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J Clin Sleep Med (2008) 4(2):1118

These drugs are essential to prevention of rejection but come at a metabolic cost, disrupting glucose metabolism through several mechanisms, including downregulation of transcription of the adiponectin gene which can lead to greater risk for glucose intolerance