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TETs, comprising TET1, TET2, and TET3, catalyze the oxidative conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxycytosin (5caC) in an Fe (II)/a-ketoglutarate-dependent manner

10.2217/14622416.8.6.567 Pharmacogenomics 67 LeeJ

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These findings suggested subtle regulatory adjustments within these pathways, potentially reflecting a complex biochemical response to the cellular state in the study (Figure 3F)