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The ggplot2 and ggpubr package of R software were used for visualization of enrichment results 36,37 , including terms, gene ratio, gene counts, P value, etc

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As the disease progresses to stage 3, systemic hyperphosphatemia typically arises, further exacerbating systemic inflammation and vascular calcification, and consequently accelerating the process of early vascular aging (Voelkl et al., 2018)