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Clinical Appropriateness Framework Combination tesofensine-semaglutide therapy may theoretically apply to individuals with severe obesity (BMI 40 or 35 with comorbidities), inadequate single-agent response, or specific metabolic phenotypes involving both central appetite dysregulation and impaired glucose homeostasis

Glucose hypometabolism in AD brain is strongly linked to impaired oxidative phosphorylation

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[Google Scholar] 72.Holst JJ, rskov C, Vagn Nielsen O, Schwartz TW

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