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Research on Combined GLP-1 and Antidepressant Use Clinical trials investigating semaglutide for weight loss (STEP 1 through STEP 5) included participants taking various psychiatric medications, including antidepressants

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10.1007/s10787-006-1531-7 116 SikiricP.SeiwerthS.BrcicL.SeverM.KlicekR.RadicB.et al (2010)

However, this review also noted that the quality of the studies was not very high, so more studies are needed before its possible to make any firm recommendations

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