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Studies show that semaglutide and tirzepatide both decrease gastric acid output while enhancing the lower esophageal sphincter's ability to prevent backflow of stomach contents

Thus, genetic silencing of the transferrin receptor limits iron accumulation and the induction of ferroptosis

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Nevertheless, further comparative in vitro studies and an animal trial should be conducted before trying it on humans

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A landmark 2023 study published in JAMA found that GLP-1 agonist users experienced increased risks of gastrointestinal adverse events (with gastroparesis risk elevated compared to patients using other diabetes medications), while a 2024 case report in PMC documented the strong relationship between semaglutide use and gastroparesis symptoms that resolved only after drug discontinuation