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The choice depends on the patients specific needs and the doctors evaluation

In addition to the increased energy expenditure and lipid oxidation, reduced food intake, also described as an effect of oral butyrate supplementation but not an intravenous injection, may contribute to decreased body weight gain induced by butyrate and reduced fat mass (51)

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People with conditions such as Lebers disease, cobalt allergies, or known sensitivity to vitamin B12 should not receive these injections