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Quite remarkably, in those with low POP levels, the typically robust association between diabetes and obesity was not observed in a nested case-controlled study, suggesting that obesity may exaggerate the metabolic disturbances caused by POPs (perhaps because adipose tissue provides a reservoir for fat-soluble toxins), rather than being directly responsible for the altered metabolism

Terrier P, Townsend AJ, Coindre JM, Triche TJ, Cowan KH (October 1990)

This is one of the theoretical advantages of the dual GIP/GLP-1 approach over the amylin/GLP-1 approach

H., Dawson-Hughes, B., Lips, P., Munns, C

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Its regulatory status within the FDA's compounding framework is under active review, with a Pharmacy Compounding Advisory Committee evaluation scheduled for July 2026