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This includes the secretion of nitric oxide for vasodilation and endothelin-1 for vasoconstriction, which modulates vascular tension and diameter, directly influencing the balance of oxygen supply to meet tissue metabolic demands

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used in long-term human clinical trials Intravenous injection Used primarily for pharmacokinetic characterization and acute dosing studies in humans Intraperitoneal injection Standard route for chronic rodent studies

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