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A pharmacokinetic and dosing study of intravenous insulin-like growth factor-I and IGF-binding protein-3 complex to preterm infants

The protocol is reported according to SPIRIT guidelines, modified through inclusion of estimand framework (30)

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Therefore, timely prevention and therapy of atherosclerosis are able to reduce the risk of the development of its clinical manifestations

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Since human kidney maturation occurs in utero and during the first 2 years of life when lactational exposure may occur, there may be risk to the developing human kidney