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REFERENCES for Example 4

Thirdly, the "second curve" is developed

The skin brightening effect is cumulative over 812 weeks

As skin matures, it may gradually become drier, appear less firm and show more noticeable fine lines

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Therefore, depletion of NADPH stores in G6PD-d has the potential to both limit the production of ROS by NOX family enzymes, while simultaneously expediting the accumulation of ROS from non-NADPH-dependent sources, such as the mitochondrial electron transport chain, peroxisomal -oxidation, oxidative protein folding, and other cytoplasmic enzymes (xanthine oxidase, cyclooxygenase, lipoxygenase) 95,96