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This is not a neutral finding

How Wegovy and Phentermine Work Differently To understand why someone might consider combining these two medications, it is helpful to look at how they function individually

Improves insulin sensitivity and cardiovascular markers

This is because, in comparison to GLP-1, semaglutide has two amino acid substitutions, which makes it less vulnerable to degradation by the proteolytic enzyme dipeptidyl peptidase-4 (DPP-4) [97] and gives it the distinct advantage of increased albumin affinity [96]

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Contraindications will likely include a history of medullary thyroid cancer or MEN 2 syndrome, and pregnancy