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Regarding safety, the majority of reported adverse events were mild to moderate, ranging from 88% to 96%, depending on the specific study group

2 The Effects of GLP-1RAs on osteoclasts and osteoblasts

those in the placebo group only lost 2.4%

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The reduction in blood pressure after receiving SGLT-2i is also caused by the effect of these drugs on natriuresis, osmotic diuresis, and regulation of the autonomic nervous system [64]