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The precise mechanism of kidney-protective effects of GLP-1 RAs still remains elusive, but likely include direct kidney actions such as inducing natriuresis through NHE3 inhibition in the proximal tubules, suppressing the intrarenal renin-angiotensin system, ameliorating kidney ischemia/hypoxia [63, 64]

Molecules (2018) 23(1):91

These preliminary results, though reassuring, need validation in larger cohorts, especially due to the narrow therapeutic range of tacrolimus and the risk for graft rejection in undertreatment

MM/PBSA or MM/Generalized Born Surface Area (GBSA) calculates the binding free energy, providing quantitative estimates of binding affinity

I have also used it in my protein shakes