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Heterogeneity of stage IIIA leads to difficulty in determining optimal treatment

Its most robust research is in healing the GI tract

This complex interplay within the gut-kidney axis not only accelerates renal functional decline, but also diminishes patients' quality of life by altering nutritional metabolism and increasing the incidence of cardiovascular complications [42, 75]

It has been shown that Nrf2 modulates the GSH redox state via glutathione reductase regulation