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As a long-acting IGF-1 analog, the compound represents a research subject in the broader field of peptide stability engineering specifically the use of structural modifications including N-terminal extension and amino acid substitution strategies to extend peptide half-life and modify peptide-binding protein interactions compared to native IGF-1 sequences

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For patients with known diabetic retinopathy who are candidates for GLP-1 therapy, additional precautions are warranted