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Over a maximum follow-up of 7.5 years, NAION developed in 0.29% of semaglutide initiators compared with 0.13% of those starting an SGLT2 inhibitor. While the relative risk was roughly twofold higher with semaglutide, the absolute risk remained low, translating to approximately one additional case per several thousand treated patients

The two main candidate molecules that fulfill criteria for an incretin are glucagon-like peptide-1 (GLP-1) and Gastric inhibitory peptide (or glucose-dependent insulinotropic polypeptide or GIP)

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