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When food enters the digestive system, GLP-1 is released and acts on multiple targets: it stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and promotes satiety through central nervous system pathways

The third receptor (glucagon) makes retatrutide unique among current weight loss medications

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If you have cardiovascular disease along with either obesity or overweight, your doctor may prescribe Wegovy, as the FDA recently approved its use for helping reduce the risk of serious cardiovascular events in some patients