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In addition, the effectiveness of a once-daily oral formulation is important as it provides an easier therapeutic option for those who may be more frail or may not have the capability for taking injections, for instance

Use of LANTUS for this indication is supported by evidence from an adequate and well-controlled study (Study D) in 174 LANTUS-treated pediatric patients aged 6 to 15 years with type 1 diabetes mellitus, and from adequate and well-controlled studies of LANTUS in adults with diabetes mellitus [see Clinical Pharmacology (12.3), Clinical Studies (14.2)]

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PMID 23826593

27,37 Transcriptionally, regulators such as c-Myc, 38 E2F1, 39 and p53 40 can either positively or negatively modulate SIRT1 promoter activity

Tolerability: Are you able to go about your daily life without significant gastrointestinal distress